Zura Bio Appoints Arnout Ploos van Amstel to its Board of Directors
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With a career spanning over three decades in the global biotech and pharmaceutical sector,
“On behalf of Zura Bio’s Board of Directors, I am pleased to extend a warm welcome to Arnout as our newest addition to the Board," announced Dr. Someit Sidhu, CEO and Director of Zura Bio. "With an impressive career spanning several decades, his expertise in strategy and business transformations brings a valuable dimension to our Board. His leadership will undoubtedly be a significant asset as we work towards creating sustained value for our company.”
"I am honored to join the Board of Directors at Zura Bio and enthusiastic about collaborating with this exceptionally skilled team that is dedicated to making a transformational impact on the lives of patients worldwide,” commented
"The Board and I would like to extend our sincere gratitude to Garry for his valuable contributions and dedication during his tenure on the Board. It brings me great pleasure to know that the Zura Bio team will continue to benefit from his guidance in an advisory capacity as our R&D organization prepares for an important year ahead, marked by the initiation of trials. With the recent addition of Arnout to our Board, we are positioned to maintain an experienced and diverse Board, characterized by complementary expertise and a shared vision," concluded
ABOUT ZURA BIO
Zura Bio is a multi-asset clinical-stage biotechnology company focused on developing novel medicines for immune and inflammatory disorders. Currently, Zura Bio is developing three assets which have completed Phase 1/1b studies and are Phase 2 ready. The company is developing a portfolio of therapeutic indications for ZB-106 (tibulizumab), ZB-168, and ZB-880 (torudokimab) with a goal of demonstrating their efficacy, safety, and dosing convenience in immune and inflammatory disorders, including systemic sclerosis, hidradenitis suppurativa, and other novel indications with unmet needs.
ABOUT ZB-106 (tibulizumab)
ZB-106 (tibulizumab) is a potential first-in-class, anti-IL-17 and anti-BAFF dual antagonist that Zura Bio plans to develop for the treatment of systemic sclerosis and hidradenitis suppurativa. ZB-106 is an IgG-scFv bispecific dual-antagonist antibody engineered by the fusion of Taltz® (ixekizumab) and tabalumab that neutralizes IL-17A and BAFF. ZB-106 has been assessed in two Phase 1b studies completed in rheumatoid arthritis and Sjögren's syndrome. The safety profile to date appears to be acceptable, with no new findings relative to known IL-17 and BAFF inhibitors. Chronic toxicology studies have been completed with no adverse drug-related findings. Phase 2 clinical trials of ZB-106 in systemic sclerosis and hidradenitis suppurativa are planned to initiate 2H-2024.
ZB-168 is a fully human, high affinity monoclonal antibody that binds and neutralizes the IL-7 receptor chain (“IL-7R”) alpha. IL-7Rα sits at the nexus of two key immune pathways (IL-7 and TSLP), thus inhibiting IL-7Rα has the potential to block activation through both of these pathways. As a result, we believe ZB-168 could be therapeutically beneficial in a broad set of indications where the IL-7 or TSLP pathways may be involved. ZB-168 has been assessed in Phase 1/1b clinical studies in Type 1 diabetes and multiple sclerosis. Safety and pharmacokinetics were evaluated and the safety profiles from these studies support further development. A Phase 2 clinical trial of ZB-168 in alopecia areata is planned to initiate in 2024.
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Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. You should carefully consider the risks and uncertainties described in the “Risk Factors” sections of Zura Bio’s recent filings with the
Head of Investor Relations